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Learn More. In the body, it converts to psilocin, which has psychedelic properties similar to those of LSD and mescaline. InSwiss chemist Albert Hofmann and co-workers isolated psilocybin and smaller amounts of psilocin from the mushroom P. More than 20 years earlier, Hofmann began to study LSD, including ingesting it himself. Hofmann and Franz Troxler reported the synthesis of psilocybin in a patent. Forty years later, Osamu Shirota and colleagues at the National Institute of Health Sciences Tokyo developed an efficient large-scale synthesis.
But What chemical is in shrooms recently, the biosynthesis of psilocybin was a mystery. Because the hallucinogen is of interest to pharmaceutical researchers as a basis for useful drugs, Dirk Hoffmeister and colleagues at Friedrich Schiller University Jena, Germany delved into the biosynthesis and identified four enzymes that mushrooms use to make the compound.
They then sequenced the genomes of two mushroom species to find the genes that cause the fungi to produce psilocybin. Finally, the researchers used three of the enzymes to synthesize psilocybin from 4-hydroxy-L-tryptophan in one pot. Learn more about this molecule from CASthe most authoritative and comprehensive source for chemical information.
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Discover Chemistry Explore the interesting world of science with articles, videos and more. Awards Recognizing and celebrating excellence in chemistry and celebrate your achievements. Funding Funding to support the advancement of the chemical sciences through research projects. My psychedelic properties may lead to new drugs.
What molecule am I? Psilocybin fast facts. CAS Reg. Molecule of the Week needs your suggestions!What chemical is in shrooms
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Beyond Psilocybin: Mushrooms Have Lots of Cool Compounds Scientists Should Study